GIANLUCA LAVANCO - Admis au titre de docteur

Adresse Professionnelle
Neurocentre Magendie 146, rue Léo Saignat 33000
BORDEAUX FRANCE
gianlucalavanco@gmail.com

Doctorat Neurosciences

Thèse soutenue le 25 janvier 2022 - Université de Bordeaux

Ecole doctorale : Sciences de la Vie et de la Santé

Sujet : Rôle du récepteur CB1 cellulaire et subcellulaire dans les cellules D1-positives de l'hippocampe sur les processus de mémoire

Mots-clés de la thèse : récepteur mtCB1,cellules D1-positives,récepteur CB1,mémoire,

Direction de thèse : Giovanni MARSICANO

Co-direction de thèse : Filippo DRAGO

Cotutelle UNIVERSITÀ DEGLI STUDI DI CATANIA ITALIE
Descriptif : The endocannabinoid system (ECS) has been shown to regulate synaptic plasticity and memory formation in the hippocampus. Cannabinoid type-1 (CB1) receptor is present in many cell types in this brain region, such as principal glutamatergic neurons, GABAergic neurons and astrocytes. Indeed CB1 receptor in astrocytes, but not in neurons, strongly modulates different form of long-term synaptic plasticity, and subsequently regulates memory process. The proposed PhD research project will focus on the mechanisms underlying the regulation of synaptic plasticity and memory formation trough the ECS. The applicant will characterize different forms of synaptic plasticity in vivo, such as long term depression and potentiation (LTD and LTP) by combining pharmacological, pharmacogenetic and genetic tools that interfere with the activation of the ECS in different cell types. Furthermore, the applicant will use the same kind of manipulations in different cognitive tasks aimed at studying short term working memory and long term memory, which are both modulated by the ECS in the hippocampus. This project aims at finding a link between the ECS-mediated modulation of synaptic plasticity and how this modulation can impact memory formation. At the end of the project, the applicant will possess a strong background in in vivo electrophysiology as well as in the behavioral study of memory processes combined with the ability to use pharmacology and genetic tools suitable for research in these fields.

Unité de recherche : Neurocentre Magendie UMR 1215 - Bordeaux
Intitulé de l'équipe : Endocannabinoïdes et neuroadaptation

Pharmacie - PHARMACIE

obtenu en octobre 2015 - Université de Palerme
Option : CHIMIE ET TECHNOLOGIE PHARMACEUTIQUE

Production scientifique

- Anna Brancato, Valentina Castelli, Gianluca Lavanco, Giuseppe Tringali, Vincenzo Micale, Martin Kuchar, Cesare d'Amico, Giuseppe Pizzolanti, Salvatore Feo, Carla Cannizzaro 2021. Binge-like alcohol exposure in adolescence: behavioural, neuroendocrine and molecular evidence of abnormal neuroplasticity and return Biomedicines, 9, https://hal.archives-ouvertes.fr/hal-03438874/document
- Maurizio Casarrubea, Manfredi Palacino, Anna Brancato, Gianluca Lavanco, Carla Cannizzaro, Giuseppe Crescimanno 2021. Detection of a temporal structure in the rat behavioural response to an aversive stimulation in the emotional object recognition (EOR) task. Physiology and Behavior, 238,
- Jose F. Oliveira da Cruz, Arnau Busquets-Garcia, Zhe Zhao, Marjorie Varilh, Gianluca Lavanco, Luigi Bellocchio, Laurie Robin, Astrid Cannich, Francisca Julio-Kalajzi, Thierry Lesté-Lasserre, Marlène Maître, Filippo Drago, Giovanni Marsicano, Edgar Soria-Gómez 2020. Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory Cell Reports, 32, pp.108046,

Dernière mise à jour le 14 février 2022