Université de Bordeaux

Mariella SPALATO CERUSO - Admise au titre de docteur


Adresse Professionnelle
229 Cours de l'Argonne 33000
CAUDERAN FRANCE
mariella.spalato@gmail.com

Projet professionnel :
  • médecin chercheur

Doctorat Biologie Cellulaire et Physiopathologie


Thèse soutenue le 16 décembre 2024 - Université de Bordeaux

Ecole doctorale : Sciences de la Vie et de la Santé

Sujet : Profil génomique et immunologique des sarcomes métastatiques des tissus mous

Mots-clés de la thèse : sarcome des tissus mous,profil génomique,profil immunologique,

Direction de thèse : Antoine ITALIANO

Unité de recherche : BoRdeaux Institute of onCology UMR 1312 - BORDEAUX

Master Européen - Génétique moléculaire et cellulaire

obtenu en 2020 - Université de Bordeaux
Option : Génétique moléculaire et cellulaire

Production scientifique

- S. Cousin, C. A. Bellera, J.-P. Guégan, T. Mazard, C. A. Gomez-Roca, J.-P. Metges, C. Cantare, A. Adenis, I. Korakis, P.-G. Poureau, M. Spalato-Ceruso, K. Bourcier, M. Kind, I. Soubeyran, A. Bessede, A. Italiano 2021. Regomune: A phase II study of regorafenib + avelumab in solid tumors—Results of the biliary tract cancer (BTC) cohort.   Poste : Abstract 4096, 1, Abstract 4096 ASCO 2021
- Mariella Spalato Ceruso, Antoine Italiano 2021. The safety of current pharmacotherapeutic strategies for osteosarcoma   Expert opinion on drug safety, Expert Opin Drug Saf. 2021 Apr;20(4):427-438., https://doi.org/10.1080/14740338.2021.1881060
- A Bessede, A Marabelle, J P Guégan, F X Danlos, S Cousin, F Peyraud, N Chaput, M Spalato, G Roubaud, M Cabart, M Khettab, A Chaibi, C Rey, I Nafia, F X Mahon, J C Soria, A Italiano 2022. Impact of acetaminophen on the efficacy of immunotherapy in cancer patients   Annals Oncology, S0923-7534(22)01208-X, 10.1016/j.annonc.2022.05.010
- A Italiano, A Bessede, M Pulido, E Bompas, S Piperno-Neumann, C Chevreau, N Penel, F Bertucci, M Toulmonde, C Bellera, J P Guegan, C Rey, C Sautès-Fridman, A Bougoüin, C Cantarel, M Kind, M Spalato, B Dadone-Montaudie, F Le Loarer, J Y Blay, W H Fridman 2022. Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort   Nature Medecine, 28(6):1199-1206, 10.1038/s41591-022-01821-3
- Mariella Spalato-Ceruso, Nathan El Ghazzi, Antoine Italiano 2024. New strategies in soft tissue sarcoma treatment   Journal of Hematology and Oncology, 17, https://hal.science/hal-04695699v1
- Cheng-Ming Sun, Maud Toulmonde, Mariella Spalato-Ceruso, Florent Peyraud, Alban Bessede, Michèle Kind, Sophie Cousin, Xavier Buy, Jean Palussiere, Antoine Bougouin, Catherine Sautès-Fridman, Hervé Wolf Fridman, Marina Pulido, Antoine Italiano 2024. Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study   Molecular Cancer, 23, pp.37, https://hal.science/hal-04694394v1
- Maud Toulmonde, Jean-Philippe Guegan, Mariella Spalato-Ceruso, Florent Peyraud, Michèle Kind, Lucile Vanhersecke, François Le Loarer, Raul Perret, Coralie Cantarel, Carine Bellera, Alban Bessede, Antoine Italiano 2024. Reshaping the tumor microenvironment of cold soft-tissue sarcomas with oncolytic viral therapy: a phase 2 trial of intratumoral JX-594 combined with avelumab and low-dose cyclophosphamide   Molecular Cancer, 23, pp.38, https://hal.science/hal-04694389v1
- Maud Toulmonde, Jean-Philippe Guegan, Mariella Spalato-Ceruso, Florent Peyraud, Michele Kind, Lucile Vanhersecke, Francois Le Loarer, Raul Perret, Coralie Cantarel, Carine Bellera, Alban Bessede, Antoine Italiano 2024. Reshaping the tumor microenvironment of cold soft-tissue sarcomas with oncolytic viral therapy: a phase 2 trial of intratumoral JX-594 combined with avelumab and low-dose cyclophosphamide   Molecular Cancer, 23, pp.38, https://hal.science/hal-04501656v1
- Xavier Buy, Cheng-Ming Sun, Maud Toulmonde, Mariella Spalato-Ceruso, Florent Peyraud, Alban Bessede, Michèle Kind, Sophie Cousin, Jean Palussiere, Antoine Bougouin, Catherine Sautès-Fridman, Hervé Wolf Fridman, Marina Pulido, Antoine Italiano 2024. Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study   Molecular Cancer, 23, pp.37, https://u-paris.hal.science/hal-04583146v1
- Sofiane Taleb, Maxime Brunet, Laila Belcaid, Rastislav Bahleda, Benjamin Verret, Axel Le Cesne, Florent Peyraud, Mariella Spalato-Ceruso, Maud Toulmonde, Antoine Italiano 2024. Prognostic significance of plasma circulating tumor DNA fraction in patients with advanced sarcoma: A French Sarcoma Group study.   , 42, pp.11574-11574, https://hal.science/hal-04694557v1
- Antoine Italiano, Jean-Philippe Guegan, Thibaud Valentin, Rastilav Bahleda, Jean Philippe Metges, Philippe Alexandre Cassier, Maud Toulmonde, Mariella Spalato-Ceruso, Florent Peyraud, Jean Palussière, Michèle Kind, Coralie Cantarel, Carine Bellera, Alban Bessede 2024. Reshaping the tumor microenvironment of cold soft-tissue sarcomas with anti-VEGFR targeted therapy: A Phase 2 Trial of Regorafenib combined with avelumab.   , 42, pp.11516-11516, https://hal.science/hal-04694549v1
- Julie Blanchi, Sofiane Taleb, Arnaud Bayle, Benjamin Verret, Maud Toulmonde, Mariella Spalatoceruso, Paul Dubos, Yech'An Laizet, Melissa Alame, Emmanuel Khalifa, Antoine Italiano 2023. Clinical utility of circulating tumor DNA sequencing with a large panel in patients with advanced softtissue sarcomas   Cancer Communications, 43, pp.1051 - 1054, https://inserm.hal.science/inserm-04538185v1
- Arnaud Bayle, Laila Belcaid, Lola-Jade Palmieri, Diego Teysonneau, Sophie Cousin, Mariella Spalato-Ceruso, Mihaela Aldea, Damien Vasseur, Melissa Alame, Laura Blouin, Isabelle Soubeyran, Claudio Nicotra, Maud Ngocamus, Antoine Hollebecque, Yohann Loriot, Benjamin Besse, Ludovic Lacroix, Etienne Rouleau, Fabrice Barlesi, Fabrice Andre, Antoine Italiano 2023. Circulating tumor DNA landscape and prognostic impact of acquired resistance to targeted therapies in cancer patients: a national center for precision medicine (PRISM) study   Molecular Cancer, 22, pp.176, https://inserm.hal.science/inserm-04521346v1
- Mariella Spalato-Ceruso, Fanny Bouteiller, Jean-Philippe Guegan, Maud Toulmonde, Alban Bessede, Michèle Kind, Sophie Cousin, Xavier Buy, Jean Palussiere, François Le Loarer, Berengere Dadone-Montaudie, Marina Pulido, Antoine Italiano 2022. Pembrolizumab combined with low-dose cyclophosphamide and intra-tumoral injection of the toll-like receptor 4 agonist G100 in patients with advanced pretreated soft tissue sarcoma: results from the PEMBROSARC basket study   Journal of Hematology and Oncology, 15, https://hal.science/hal-04695749v1
- Florent Peyraud, Jean-Philippe Guegan, Christophe Rey, Marina Pulido, Emmanuelle Bompas, Sophie Piperno-Neumann, Christine Chevreau, Nicolas Penel, François Bertucci, Maud Toulmonde, Carine Bellera, Catherine Sautès-Fridman, Antoine Bougoüin, Coralie Cantarel, Michèle Kind, Mariella Spalato-Ceruso, Bérengère Dadone-Montaudie, Jean-Yves Blay, Wolf Herman Fridman, François Le Loarer, Alban Bessede, Antoine Italiano 2022. Abstract 2578: High regulatory T cells infiltrate within tertiary lymphoid structure restricts response to immune checkpoint blockers in sarcomas   , 82, pp.2578-2578, https://hal.science/hal-04694521v1

Langues Vivantes : Français C2 - Courant - Anglais B2 - Intermédiaire supérieur - Italien C2 - Maternel
Dernière mise à jour le 3 novembre 2024