Université de Bordeaux
photo

Florent PEYRAUD - Soutenance en cours de traitement


Adresse Professionnelle
229 cours de l'Argonne 33000
BORDEAUX FRANCE
peyraud.florent@gmail.com
Identifiant ORCID 0000000174382847
Identifiant Hal https://hal.archives-ouvertes.fr/search/index/?q=%2A&authIdHal_s=1573249
Compte Researchgate https://www.researchgate.net/profile/Florent-Peyraud

Projet professionnel :
  • Enseignement et recherche, enseignement supérieur
  • Recherche en milieu académique
  • Pilotage de la recherche et de l’innovation, gestion de projets innovants, pilotage de structures innovantes
  • enseignant-chercheur, enseignant du supérieur
  • chercheur en milieu académique
  • pilotage de la recherche et de l’innovation, gestion de projets innovants, pilotage de structures innovantes
  • médiation scientifique, communication et journalisme scientifique, édition scientifique, relations internationales

Doctorat Biologie du cancer


Thèse soutenue le 10 décembre 2024 - Université de Bordeaux

Ecole doctorale : Sciences de la Vie et de la Santé

Sujet : PRIORY : Caractérisation et rôle des cellules B et des structures lymphoïdes tertiaires chez les patients atteints de cancer et traités par immunothérapie.

Mots-clés de la thèse : Structure lymphoïde tertiaire,Cellules B,Immunothérapie,Tumeur solide,Cancer du poumon,

Direction de thèse : Antoine ITALIANO

Unité de recherche : BoRdeaux Institute of onCology UMR 1312 - BORDEAUX
Intitulé de l'équipe : Sarcotarget

Master - Biologie Santé - Master 2

obtenu en juin 2020 - Université de Paris-XI
Option : Pharmacologie thérapeutique

Production scientifique

- Thomas Chevalier, Amaury Daste, Esmaa Saadabouzid, Anderson Loundou, Florent Peyraud, Tiphaine Lambert, Christophe Le Tourneau, Frédéric Peyrade, Charlotte Dupuis, Marc Alfonsi, Jérôme Fayette, Juliette Reure, Florence Huguet, Nicolas Fakhry, Clémence Toullec, Sébastien Salas 2021. Cetuximab combined with paclitaxel or paclitaxel alone for patients with recurrent or metastatic head and neck squamous cell carcinoma progressing after EXTREME   Cancer Medicine, , https://hal.sorbonne-universite.fr/hal-03242636/document
- Florent Peyraud 2021. Métabolites circulants de la voie du tryptophane et réponse à l'immunothérapie chez les patients atteints de cancer : valeur prédictive et mécanisme de résistance Circulating Tryptophan Predicts Survival and Response to Immune Checkpoint Inhibitors in Patients with Advanced Solid Tumors   , pp.120, https://dumas.ccsd.cnrs.fr/dumas-03352840/document
- F Peyraud 1 , J-P Guégan 2 , D Bodet 2 , I Nafia 2 , L Fontan 2 , C Auzanneau 3 , S Cousin 4 , G Roubaud 4 , M Cabart 4 , F Chomy 4 , F Le Loarer 3 , N Chaput 5 , F-X Danlos 6 , D Planchard 7 , C Even 7 , M Khettab 7 , L Tselikas 8 , B Besse 7 , F Barlesi 7 , J-C Soria 7 , A Marabelle 9 , A Bessede 2 , A Italiano 10 2022. Circulating L-arginine predicts the survival of cancer patients treated with immune checkpoint inhibitors   Annals of oncology, 10.1016/j.annonc.2022.07.001, https://linkinghub.elsevier.com/retrieve/pii/S0923-7534(22)01827-0
- A Bayle 1 , F Peyraud 2 , L Belcaid 3 , M Brunet 4 , M Aldea 5 , R Clodion 6 , P Dubos 4 , D Vasseur 7 , C Nicotra 6 , A Geraud 6 , M Sakkal 6 , L Cerbone 8 , F Blanc-Durand 8 , F Mosele 8 , P Martin Romano 6 , M Ngo Camus 6 , I Soubeyran 9 , E Khalifa 9 , M Alame 9 , L Blouin 9 , D Dinart 10 , C Bellera 10 , A Hollebecque 6 , S Ponce 6 , Y Loriot 6 , B Besse 5 , Ludovic Lacroix 7 , E Rouleau 7 , F Barlesi 11 , F Andre 5 , A Italiano 12 2022. Liquid versus tissue biopsy for detecting actionable alterations according to ESCAT in patients with advanced cancer: A study from the French National Center for Precision Medicine (PRISM)   Annals of oncology, 10.1016/j.annonc.2022.08.089, https://linkinghub.elsevier.com/retrieve/pii/S0923-7534(22)04147-3
- Maud Toulmonde, Jean-Philippe Guegan, Mariella Spalato-Ceruso, Florent Peyraud, Michèle Kind, Lucile Vanhersecke, François Le Loarer, Raul Perret, Coralie Cantarel, Carine Bellera, Alban Bessede, Antoine Italiano 2024. Reshaping the tumor microenvironment of cold soft-tissue sarcomas with oncolytic viral therapy: a phase 2 trial of intratumoral JX-594 combined with avelumab and low-dose cyclophosphamide   Molecular Cancer, 23, pp.38, https://hal.science/hal-04694389
- Maud Toulmonde, Jean-Philippe Guegan, Mariella Spalato-Ceruso, Florent Peyraud, Michele Kind, Lucile Vanhersecke, Francois Le Loarer, Raul Perret, Coralie Cantarel, Carine Bellera, Alban Bessede, Antoine Italiano 2024. Reshaping the tumor microenvironment of cold soft-tissue sarcomas with oncolytic viral therapy: a phase 2 trial of intratumoral JX-594 combined with avelumab and low-dose cyclophosphamide   Molecular Cancer, 23, pp.38, https://hal.science/hal-04501656
- Xavier Buy, Cheng-Ming Sun, Maud Toulmonde, Mariella Spalato-Ceruso, Florent Peyraud, Alban Bessede, Michèle Kind, Sophie Cousin, Jean Palussiere, Antoine Bougouin, Catherine Sautès-Fridman, Hervé Wolf Fridman, Marina Pulido, Antoine Italiano 2024. Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study   Molecular Cancer, 23, pp.37, https://u-paris.hal.science/hal-04583146
- Arnauld Bayle, Laïla Belcaid, Mihaela D. Aldea, Damien Vasseur, Florent Peyraud, Claudio Nicotra, Arthur Geraud, Madona Sakkal, Lauren Seknazi, Luigi Cerbone, Félix Blanc-Durand, Julien Hadoux, Fernanda Mosele, Marco Tagliamento, Alice Bernard-Tessier, Benjamin Verret, Cristina Smolenschi, R. Clodion, Nathalie Auger, P. M. Romano, Anas Gazzah, Maud Ngo Camus, Jean Baptiste Micol, Olivier Md Msc Caron, Antoine Hollebecque, Yohann Loriot, Benjamin Besse, Ludovic Lacroix, Étienne L. Rouleau, Santiago Ponce, Jean-Charles Charles Soria, Fabrice Barlesi, Fabrice Andre, Antoine Italiano 2023. Clinical utility of circulating tumor DNA sequencing with a large panel: a National Center for Precision Medicine (PRISM) study   Annals of Oncology, 34, pp.389-396, https://hal.science/hal-04233288
- Xinwei Sher, Fredrick Gootkind, Thomas Schürpf, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, G. Travis Clifton, Laura Dillon 2024. Abstract 2916: Discoidin domain receptor 1 (DDR1) expression is associated with degree of immune exclusion across epithelial tumors   , 84, pp.2916-2916, https://hal.science/hal-04694486
- Yanchao Wang, Fredrick Gootkind, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, G. Travis Clifton, Laura Dillon, Xinwei Sher 2024. Abstract 7392: Machine learning-based identification of H&E-derived morphologic features associated with CD8+ T cell immune exclusion   , 84, pp.7392-7392, https://hal.science/hal-04694479
- Cheng-Ming Sun, Maud Toulmonde, Mariella Spalato-Ceruso, Florent Peyraud, Alban Bessede, Michèle Kind, Sophie Cousin, Xavier Buy, Jean Palussiere, Antoine Bougouin, Catherine Sautès-Fridman, Hervé Wolf Fridman, Marina Pulido, Antoine Italiano 2024. Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study   Molecular Cancer, 23, pp.37, https://hal.science/hal-04694394
- Florent Peyraud, Jean-Philippe Guegan, Lucile Vanhersecke, Christophe Rey, Oren Lara, Ophélie Odin, Emma Clot, Maxime Brunet, Thomas Grellety, Marie del Castillo, Sylvestre Le Moulec, François Le Loarer, Alban Bessede, Antoine Italiano 2024. Abstract 7471: Cancer-associated fibroblasts drive T cell infiltration and resistance to immunotherapy in non-small cell lung cancer with mature tertiary lymphoid structures   , 84, pp.7471-7471, https://hal.science/hal-04694472
- Alban Bessede, Florent Peyraud, Benjamin Besse, Sophie Cousin, Mathilde Cabart, François Chomy, Christophe Rey, Oren Lara, Ophélie Odin, Imane Nafia, Lucile Vanhersecke, Fabrice Barlesi, Jean-Philippe Guégan, Antoine Italiano 2024. TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced NonSmall Cell Lung Cancer   Clinical Cancer Research, 30, pp.779-785, https://hal.science/hal-04694396
- Sofiane Taleb, Maxime Brunet, Laila Belcaid, Rastislav Bahleda, Benjamin Verret, Axel Le Cesne, Florent Peyraud, Mariella Spalato-Ceruso, Maud Toulmonde, Antoine Italiano 2024. Prognostic significance of plasma circulating tumor DNA fraction in patients with advanced sarcoma: A French Sarcoma Group study.   , 42, pp.11574-11574, https://hal.science/hal-04694557
- Antoine Italiano, Jean-Philippe Guegan, Thibaud Valentin, Rastilav Bahleda, Jean Philippe Metges, Philippe Alexandre Cassier, Maud Toulmonde, Mariella Spalato-Ceruso, Florent Peyraud, Jean Palussière, Michèle Kind, Coralie Cantarel, Carine Bellera, Alban Bessede 2024. Reshaping the tumor microenvironment of cold soft-tissue sarcomas with anti-VEGFR targeted therapy: A Phase 2 Trial of Regorafenib combined with avelumab.   , 42, pp.11516-11516, https://hal.science/hal-04694549
- Nhat Le, Laura Dillon, Ciyue Shen, Matthew Bronnimann, Jun Zhang, Jennifer Hipp, Tan Nguyen, Michael Griffin, Michael Nercessian, Jacqueline Brosnan-Cashman, Robert Egger, Jean Philippe Guégan, Alban Bessede, Florent Peyraud, Antoine Italiano, Xinwei Sher, G. Travis Clifton, Bahar Rahsepar 2024. Correlation of immune phenotypes derived from H&E-stained whole slide images with prognosis and response to checkpoint inhibitors in NSCLC.   , 42, pp.8539-8539, https://hal.science/hal-04694562
- Florent Peyraud, Fredrick Gootkind, Antoine Italiano, Alban Bessede, Jean-Philippe Guegan, Xinwei Sher, Thomas Schürpf, Guy Clifton, Laura Dillon 2023. Abstract 2108: High prevalence of immune exclusion in cancer as determined by pathologist assessment and image analysis   , 83, pp.2108-2108, https://hal.science/hal-04694493
- Jean-Philippe Guegan, Florent Peyraud, Christophe Rey, Oren Ngouala, Ophélie Odin, Imane Nafia, Isabelle Soubeyran, Sylvestre Le Moulec, Alban Bessede, Antoine Italiano 2023. Abstract 4341: Indoleamine 2,3-dioxygenase 1 is highly expressed in tertiary lymphoid structures and associated with improved outcome in patients with advanced non-small cell lung cancer treated with anti-PD1/PDL1 inhibitors   , 83, pp.4341-4341, https://hal.science/hal-04694497
- Alban Bessede, Florent Peyraud, Sylvestre Le Moulec, Sophie Cousin, Mathilde Cabart, François Chomy, Christophe Rey, Oren Lara, Ophélie Odin, Imane Nafia, Jean-Philippe Guegan, Antoine Italiano 2023. Upregulation of Indoleamine 2,3-Dioxygenase 1 in Tumor Cells and Tertiary Lymphoid Structures is a Hallmark of Inflamed NonSmall Cell Lung Cancer   Clinical Cancer Research, 29, pp.4883-4893, https://hal.science/hal-04694402
- Florent Peyraud, Jean-Philippe Guegan, Christophe Rey, Oren Ngouala, Ophélie Odin, Emma Clot, Lucile Vanhersecke, Maxime Brunet, Thomas Grellety, Marie del Castillo, Sylvestre Le Moulec, François Le Loarer, Alban Bessede, Antoine Italiano 2023. Abstract 6767: Cancer-associated fibroblasts promote T-cell exclusion and resistance to immunotherapy in non-small cell lung cancer with tertiary lymphoid structures   , 83, pp.6767-6767, https://hal.science/hal-04694470
- Antoine Italiano, Laura Leroy, Jean-Philippe Guegan, Sophie Cousin, Florent Peyraud, Mathilde Cabart, Francois Chomy, Lucile Vanhersecke, Alban Bessede 2023. TROP2 expression and response to immune checkpoint inhibition in patients with advanced non-small cell lung cancer.   , 41, pp.9040-9040, https://hal.science/hal-04694543
- Luc Heraudet, Jean Galtier, Simon Favre, Florent Peyraud, Titouan Cazaubiel, Harmony Leroy, Nathan Mottal, Françoisxavier Gros, Edouard Forcade, Laurence Clément, Pierreyves Dumas, Arnaud Pigneux, Thibaut Leguay 2022. VANDA regimen followed by blinatumomab leads to favourable outcome in patients with Philadelphia chromosomenegative Bprecursor acute lymphoblastic leukaemia in first relapse   British Journal of Haematology, 198, pp.523-527, https://hal.science/hal-04694427
- Imane Nafia, Jean-Philippe Guegan, Assia Chaibi, Noëlie Bos, Doriane Bortolotto, Christophe Rey, Loïc Cerf, Florent Peyraud, Antoine Italiano, Alban Bessede 2022. Abstract 622: Development and characterization of a novel anti-PD1 resistant sarcoma mouse model   , 82, pp.622-622, https://hal.science/hal-04694525
- Florent Peyraud, Jean-Philippe Guegan, Dominique Bodet, Sophie Cousin, Alban Bessede, Antoine Italiano 2022. Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives   Frontiers in Immunology, 13, https://hal.science/hal-04694443
- Céline Blaye, Thomas Boyer, Florent Peyraud, Charlotte Domblides, Nicolas Larmonier 2022. Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers   Frontiers in Immunology, 13, https://hal.science/hal-04694439
- Arnaud Bayle, Laila Belcaid, Miha Aldea, Florent Peyraud, Patricia Martin Romano, Félix Blanc-Durand, Rebecca Clodion, Santiago Ponce, Claudio Nicotra, Antoine Hollebecque, Yohann Loriot, Benjamin Besse, Damien Vasseur, Ludovic Lacroix, Etienne Rouleau, Jean-Charles Soria, Fabrice Barlesi, Geoffrey Oxnard, Fabrice Andre, Antoine Italiano 2022. Abstract 3413: Clinical utility of circulating tumor DNA sequencing with a large panel: The experience of Gustave Roussy/National Center for Precision Medicine (PRISM)   , 82, pp.3413-3413, https://hal.science/hal-04694503
- Jean-Philippe Guegan, Florent Peyraud, Aurelien Marabelle, Nathalie Chaput, Dominique Bodet, Laure Fontan, Anthony Gaultier, Imane Nafia, Francois-Xavier Danlos, David Planchard, Caroline Robert, Caroline Even, Mohamed Khettab, Lambros Tselikas, Luc Friboulet, Jean-Charles Soria, Fabrice Andre, Fabrice Barlesi, Alban Bessede, Antoine Italiano 2022. Abstract 1251: Low plasma Arginine level is associated with resistance to immune checkpoint blockers in patients with advanced cancer   , 82, pp.1251-1251, https://hal.science/hal-04694506
- Arnaud Bayle, Florent Peyraud, Laila Belcaid, Maxime Brunet, Miha Aldea, Rebecca Clodion, Paul Dubos, Damien Vasseur, Claudio Nicottra, Santiago Ponce, Isabelle Soubeyran, Emmanuel Khalifa, Yohann Loriot, Benjamin Besse, Ludovic Lacroix, Etienne Rouleau, Geoffrey Oxnard, Fabrice Barlesi, Fabrice Andre, Antoine Italiano 2022. Abstract 3414: Systematic comparison of ctDNA vs tissue sequencing with a large panel to guide therapy in patients with advanced cancer: A study from the French National Center for Precision Medicine (PRISM)   , 82, pp.3414-3414, https://hal.science/hal-04694515
- Florent Peyraud, Jean-Philippe Guegan, Christophe Rey, Marina Pulido, Emmanuelle Bompas, Sophie Piperno-Neumann, Christine Chevreau, Nicolas Penel, François Bertucci, Maud Toulmonde, Carine Bellera, Catherine Sautès-Fridman, Antoine Bougoüin, Coralie Cantarel, Michèle Kind, Mariella Spalato-Ceruso, Bérengère Dadone-Montaudie, Jean-Yves Blay, Wolf Herman Fridman, François Le Loarer, Alban Bessede, Antoine Italiano 2022. Abstract 2578: High regulatory T cells infiltrate within tertiary lymphoid structure restricts response to immune checkpoint blockers in sarcomas   , 82, pp.2578-2578, https://hal.science/hal-04694521
- Alban Bessede, Aurelien Marabelle, Jean-Philippe Guegan, Florent Peyraud, François-Xavier Danlos, Sophie Cousin, Nathalie Chaput, Mariella Spalato, Guilhem Roubaud, Mathilde Cabart, Mohamed Khettab, Assia Chaibi, Christophe Rey, Imane Nafia, François-Xavier Mahon, Jean-Charles Soria, Antoine Italiano 2022. Impact of acetaminophen on the efficacy of immunotherapy in patients with cancer.   , 40, pp.12000-12000, https://hal.science/hal-04694534
- Florent Peyraud, Jean-Philippe Guegan, Christophe Rey, Sophie Cousin, Guilhem Roubaud, Mathilde Cabart, Maxime Brunet, Ezogelin Oflazoglu Gruyters, Ariel Savina, Sylvestre Le Moulec, Bérangère Dadone-Montaudon, Fabrice Barlesi, Benjamin Besse, Yohann Loriot, Aurelien Marabelle, Jean-Charles Soria, Jean-Yves Scoazec, François Le Loarer, Alban Bessede, Antoine Italiano 2022. Identification of super-exhausted T cells: A novel population predictive of response to immunotherapy.   , 40, pp.2596-2596, https://hal.science/hal-04694538
- Florent Peyraud, Mathieu Larroquette, Alain Ravaud, Marine Gross-Goupil 2021. New Insights into Adjuvant Therapy in Renal Cell Carcinoma: Is the Chapter of VEGF Inhibitors Definitely Closed?   European Urology, 80, pp.269-274, https://hal.science/hal-04694451
- Mathieu Larroquette, Florent Peyraud, Charlotte Domblides, Félix Lefort, Jean-Christophe Bernhard, Alain Ravaud, Marine Gross-Goupil 2021. Adjuvant therapy in renal cell carcinoma: Current knowledges and future perspectives   Cancer Treatment Reviews, 97, pp.102207, https://hal.science/hal-04694449
- Florent Peyraud, Antoine Italiano 2020. Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors   Cancers, 12, pp.1502, https://hal.science/hal-04694456
- T. Grellety, Florent Peyraud, N. Sevenet, O. Tredan, N. Dohollou, E. Barouk-Simonet, M. Kind, M. Longy, J.-Y. Blay, A. Italiano 2020. Dramatic response to PARP inhibition in a PALB2-mutated breast cancer: moving beyond BRCA   Annals of Oncology, 31, pp.822-823, https://hal.science/hal-04694459
- Florent Peyraud, Clément Allenet, Marine Gross-Goupil, Charlotte Domblides, Félix Lefort, Amaury Daste, Mokrane Yacoub, Thibaud Haaser, Ludovic Ferretti, Grégoire Robert, Alain Ravaud 2020. Current management and future perspectives of penile cancer: An updated review   Cancer Treatment Reviews, 90, pp.102087, https://hal.science/hal-04694452
- Florent Peyraud, Sophie Cousin, Antoine Italiano 2017. CSF-1R Inhibitor Development: Current Clinical Status   Current Oncology Reports, 19, pp.70, https://hal.science/hal-04694571

Langues Vivantes : Anglais C2 - Courant - Français C2 - Maternel - Allemand A2 - Élémentaire
Dernière mise à jour le 4 novembre 2024