William FYKE - Admis au titre de docteur

Doctorat Neurosciences

Thèse soutenue le 17 mars 2021 - Université de Bordeaux

Ecole doctorale : Sciences de la Vie et de la Santé

Sujet : Identification de cibles thérapeutiques pour le traitement du syndrome de l'X fragile: conséquences pour les troubles du spectre autistique

Mots-clés de la thèse : génétique comportementale,modèles murin,autisme,Syndrome de l'X fragile,

Direction de thèse : Susanna PIETROPAOLO

Co-direction de thèse : Juan Marcos ALARCON

Cotutelle State University of New York ETATS-UNIS
Descriptif : The student will spend two years at the University of Bordeaux and one year at SUNY Downstate working on the project titled: The role of sensory processing in mouse models of autism spectrum disorders: behavioral and molecular mechanisms

Unité de recherche : Institut de neurosciences cognitives et intégratives d'Aquitaine UMR 5287 - Bordeaux

Diplôme étranger - Bachelor of Science

obtenu en mai 2015 - State University of New York
Option : Cell/Molecular Biology with Chemistry Minor

Production scientifique

- Mendoza, R*. Fyke, W*., Daniel, D., Gabutan, E., Ballabh, D., Easy, M., Vasileva, A., Colbourn, R., Alawad, M., Dehghani, A., Lin, B., Emechebe, D., Patel, P., Jabbar, M., Ni-kolov, D. B., Giovaniello, D., Kang, S., Tatem, L., Bromberg, K., Augenbraun, M., Premsrirut, P., Libien, J., & Norin, A.J. 2021. Administration of High Titer Convalescent Anti-SARS-CoV-2 Plasma: From Donor Selection to Monitoring Recipient Outcomes Human Immunology, 82(4), 255-263., doi.org/10.1016/j.humimm.2021.02.007
- Fyke, W.*, Premoli, M.*, Alzate, V.E., López-Moreno, J.A., Lemaire-Mayo, V., Crusio, W.E., Marsicano, G., Wohr, M., & Pietropaolo, S. 2021. Communication and social interaction in the Cannabinoid-type 1 Receptor (CB1R) null mouse: Implications for Autism Spectrum Disorder Autism Research, Onliine,
- Mendoza, R. Saha, N. Momeni, A. Gabutan, E, Alawad, M. Dehghani, A. Diks, J. Lin, B. Wang, D. Alshal, M., Fyke, W., Alshal, M., Wang, B., Himanen, J., Premsrirut, P., & Nikolov, D.B. 2021. Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19 Heliyon: Cell Press, e07200, doi.org/10.1016/j.heliyon.2021.e07200
- Fyke, W.*, Alarcon, J.M., Velinov, M., & Chadman, K.K. 2021. Pharmacological inhibition of BKCa channels induces a specific social deficit in adult C57BL6/J mice Behavioral Neuroscience, Online, doi.org/10.1037/bne0000459
- Fyke, W.*, Alarcon, J.M., Velinov, M., & Chadman, K.K. 2021. Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-α, induces ASD-like and co-morbid phenotypes in adult C57BL/J mice Autism Research, Online, doi.org:10.1002/aur.2520

Dernière mise à jour le 9 juin 2021