Unai ALDUNTZIN EGIZURAIN - Admis au titre de docteur

unaialduntzin@hotmail.com
unai.alduntzin-egizurain@u-bordeaux.fr
Identifiant ORCID 0000-0003-1088-6338

Doctorat Neurosciences

Thèse soutenue le 16 décembre 2022 - Université de Bordeaux

Ecole doctorale : Sciences de la Vie et de la Santé

Sujet : Analyse de l'ubiquitination induite par UBE3A et de son rôle dans la régulation de l'excitabilité du cortex préfrontal

Mots-clés de la thèse : UBE3A,Syndrome d'Angelman,Ubiquitination,Excitabilité préfrontale,DUB,

Direction de thèse : Andréas FRICK

Co-direction de thèse : Ugo MAYOR MARTINEZ

Cotutelle UNIVERSIDAD DEL PAÍS VASCO / EUSKAL HERRIKO UNIBERTSITATEA ESPAGNE
Descriptif : The ubiquitin E3 ligase UBE3A is a critical enzyme required for appropriate brain development and function. In fact, Angelman syndrome (AS) and dup15q-associated autism are caused by the lack and excess of UBE3A in the brain, respectively. We recently found that UBE3A is responsible for ubiquitinating DDI1, among other proteins, in the brain but still there is a crucial gap in our understanding of the biological role of UBE3A in neurons. Aiming to fill that gap, in the present project we will focus on studying the type of UBE3A-dependent ubiquitination that occurs on DDI1 and revealing the biological effect of such modification in neurons. Characterising in vivo the substrates through which UBE3A neuronal activity is modulated will allow us to have a better understanding of the causes and symptoms related to Angelman and Dup15q syndromes, which confers to this ambitious project a multidisciplinary and transversal perspective. This is highly significant since at present there is no cure and no targetted treatment for either of those debilitating neurological disorders.

Unité de recherche : Neurocentre Magendie UMR 1215 - Bordeaux

Master - Sciences, Technologie, Santé, Mention Sciences du vivant

obtenu en juin 2017 - Université de Strasbourg
Option : Spécialité Neurosciences (Joint Master in Neuroscience)
Langues Vivantes : Espagnol C2 - Maternel - Français C2 - Maternel

Dernière mise à jour le 23 novembre 2022