Objectifs :
The process of adaptation is of fundamental importance in shaping the genome of individuals. The modern genotyping technologies and new statistical methods are giving the ability to identify individual regions of the genome that are likely to be important in adaptive process.
This doctoral course falls within the general scope of describing the most innovative methods for detection of adaptation signals, related with environmental variables.
It will alternate lectures and tutorial classes.

Programme :
Scheduling

1. General introduction on animal adaptation. Tatiana Zerjal. Monday 10h30-12 h

2. Models of population genetics and measures of the neutral diversity.
A reminder (Conference). Mathieu Gautier/Renaud Vitalis. Monday 14h-17h

3. Selection footprints.
a. General introduction. Keurcien Luu. Tuesday 9h-10h30
b. Selection footprints. Bayesian methods (PCADAPT/SELESTIM - Conference + Tutorial ). Keurcien Luu/Renaud Vitalis. Tuesday 11h-12h30 / 14h-15h30
c. the HapFLK method (HapFLK- Conference + Tutorial). Simon Boitard. Tuesday 16h00-17h30 / Wednesday 9h-10h30

4. Links with environmental covariables.
a. Factorial methods (PCAIV, Redudancy analysis – Conference + Tutorial). Denis Laloë. Thursday 14h-17h
b. BayPass (Cours+TD). Mathieu Gautier. Thursday 9h00-12h00
c. Factor analysis (LFMM/LEA- Conference + Tutorial). Olivier François. Thursday 14h00-17h00


5. Functional analysis
a. Characterization of selection regions; functional analysis of candidate genes; Functions identifying and viewing - Conference. Laurence Flori. Friday 9h00-10h30.

6. Conclusion. Friday 11h00-12h30

Pré-requis :
Prerequisites are: basic knowledge in population genetics and statistics, and R software.

Equipe pédagogique :
LALOE Denis denis.laloe@jouy.inra.fr

Compétences acquises à l'issue de la formation :
At the end of the training, every PhD student will be able to undertake this kind of studies using a wide range of innovative methods.

http://www6.jouy.inra.fr/gabi_eng/Who-are-we/Directory-of-GABI-members/LALOE-Denis