Programme :
Part 1 – Introduction and Chemistry Applications of Biomolecules (6h)

This course begins with a brief overview of LabEx ARCANE, a Grenoble-based consortium uniting laboratories around molecular chemistry to develop new energy sources, future medical treatments, and advanced diagnostic tools. Its multidisciplinary work centers on designing, synthesizing, and applying novel biomolecules and nano-objects.

We will then explore the chemical synthesis of key biopolymers, peptides, oligonucleotides, and saccharides, focusing on foundational synthetic strategies and protecting-group tactics for controlled, step-by-step assembly. Connections to drug discovery and advanced biomaterials will be highlighted.
The second lecture will cover nucleic acids, emphasizing the phosphoramidite method for solid-phase synthesis and the growing role of synthetic oligonucleotides in diagnostics, therapeutics, and biotechnology.
The third session provides hands-on laboratory training, where students will synthesize peptides and oligonucleotides using solid-phase techniques.

Part 2 – Innovative Approaches to Discover Biologically Active Molecules from Complex Natural Mixtures (5h)

Various methods exist for discovering new biologically active molecules. Chemically modified natural products, which bridge the gap between natural and synthetic molecules, expand accessible chemical space. Recent advances include innovative techniques that directly modify complex mixtures such as natural product extracts, addressing long-standing challenges in natural product chemistry.

Part 3 – Artificial Metalloenzymes and Molecular Catalysts: Sustainable and Bio-Inspired Chemistry (6h)

This course explores how catalysis can improve chemical processes within the framework of sustainable and bio-inspired chemistry. We begin with an introduction to the principles of green chemistry and bio-inspiration, with applications in fine chemicals, pharmaceuticals, and energy carriers.

We then focus on artificial metalloenzymes, from their design to their catalytic applications across diverse reactions. The course continues with molecular catalysts, including cascade and tandem catalysis, which enable single-step transformations, reduce waste, and lower energy consumption. Molecular complexes will be studied for their ability to orchestrate multiple reactions selectively and efficiently.
Participants will examine how these approaches reduce environmental impact and promote greener practices, along with recent advances and remaining challenges in the field.

Part 4 – Colloidal Semiconductor Nanocrystals (Quantum Dots) – Synthesis and Applications (3h)

A first session will present the state of the art in colloidal semiconductor nanocrystals (quantum dots), a field recently recognized by the Nobel Prize in Chemistry. Topics include nucleation and growth mechanisms, molecular precursors and ligands, and the influence of parameters on nanocrystal properties. Different NC families will be discussed, from traditional CdS(e) to cadmium-free Cu(Ag)InS₂, InP, and the more recent halide perovskites. Surface functionalization and its impact on optical properties, solubility, and stability will also be covered.
Then applications of nanocrystals will be examined, including bio-labeling, solar cells, photodetectors, LEDs, and photocatalysis. Emphasis will be placed on how composition, size, and functionalization influence device performance. Recent advances from ARCANE partner labs will be presented, as well as ongoing challenges such as toxicity, stability, and fundamental understanding, with perspectives on future directions.